C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877419" target="_blank" >RIV/62157124:16370/19:43877419 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s11101-019-09641-z" target="_blank" >https://link.springer.com/article/10.1007/s11101-019-09641-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-019-09641-z" target="_blank" >10.1007/s11101-019-09641-z</a>

Result language

angličtina

Original language name

C-prenylated flavonoids with potential cytotoxic activity against solid tumor cell lines

Original language description

Natural products of plant origin or their semisynthetic derivatives acting as chemopreventive or chemotherapeutic agents for various types of cancer are under study as potential new anticancer drugs. Within the huge class of plant phenolic secondary metabolites, the subclass of prenylated flavonoids is quite rich in structural variety and pharmacological activity. One of their most prominent characteristics is their potential as anticancer agents. The aim of this review is to summarize the available data about the cytotoxicity of C-prenylated flavonoids on solid tumor cell lines as shown by in vitro assays. Prenylated flavonoids are divided into groups according to the prenyl substitution of the flavonoid skeleton. Within these flavonoid groups, attention is focused on flavones, flavonols, flavanones, dihydroflavonols, and isoflavonoids. This search is limited to compounds that do not contain heteroatoms other than oxygen, and is focused only on aglycones. Attempts to compare the bioassay results obtained from the search reveal complications caused by the use of different assay protocols, different ranges of concentration studied, different times the cell cultures were exposed to the compounds being assayed, and in some cases the lack of a proper positive control. In vivo assays of the anticancer activity of prenylated flavonoids on solid tumors were also reviewed. Despite the difficulties in comparing them, it is clear that the C-prenylated flavonoid class possesses significant bioactivity, suggesting a potential role for such compounds in anticancer drug discovery and development. [GRAPHICS] .

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10611 - Plant sciences, botany

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytochemistry Reviews

ISSN

1568-7767

e-ISSN

—

Volume of the periodical

18

Issue of the periodical within the volume

Jan

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

50

Pages from-to

1051-1100

UT code for WoS article

000496695300006

EID of the result in the Scopus database

2-s2.0-85073821528