Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit (R) Polymers as a Part of Hypromellose K100M Matrix Systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877714" target="_blank" >RIV/62157124:16370/19:43877714 - isvavai.cz</a>
Result on the web
<a href="https://www.hindawi.com/journals/bmri/2019/8043415/" target="_blank" >https://www.hindawi.com/journals/bmri/2019/8043415/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/8043415" target="_blank" >10.1155/2019/8043415</a>
Alternative languages
Result language
angličtina
Original language name
Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit (R) Polymers as a Part of Hypromellose K100M Matrix Systems
Original language description
The aim of the present study was to investigate the suitability of insoluble Eudragit (R) water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolution behavior, drug release mechanism and kinetics, texture profile analysis of the gel layer, and PCA analysis were explored. An application of water dispersions directly on levetiracetam was feasible only in a multistep process. All prepared formulations exhibited a 12-hour sustained release profile characterized by a reduced burst effect in a concentration-dependent manner. No effect on swelling extent of HPMC K100M was observed in the presence of Eudragit (R). Contrary, higher rigidity of formed gel layer was observed using combination of HPMC and Eudragit (R). Not only the type and concentration of Eudragit (R), but also the presence of the surfactant in water dispersions played a key role in the dissolution characteristics. The dissolution profile close to zero-order kinetic was achieved from the sample containing levetiracetam directly granulated by the water dispersion of Eudragit (R) NE (5% of solid polymer per tablet) with a relatively high amount of surfactant nonoxynol 100 (1.5%). The initial burst release of drug was reduced to 8.04% in 30 min (a 64.2% decrease) while the total amount of the released drug was retained (97.02%).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2019
Issue of the periodical within the volume
ID8043415
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
000461616600001
EID of the result in the Scopus database
2-s2.0-85063271286