New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877765" target="_blank" >RIV/62157124:16370/19:43877765 - isvavai.cz</a>
Result on the web
<a href="https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2019-4-8/new-approach-for-detoxification-of-patients-dependent-on-benzodiazepines-and-z-drugs-for-reduction-of-psychogenic-complications-118489" target="_blank" >https://www.prolekare.cz/en/journals/czech-and-slovak-pharmacy/2019-4-8/new-approach-for-detoxification-of-patients-dependent-on-benzodiazepines-and-z-drugs-for-reduction-of-psychogenic-complications-118489</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications
Original language description
Benzodiazepines (BZDs) and Z-drugs are strongly addictive substances. Detoxification should be long-term and gradual, usually by tapering a long-acting BZD (diazepam) but no suitable commercial pharmaceutic product exists with the necessary low drug content. This review describes the specific pharmacological aspects and comparisons of individual BZDs in relation to their effects and addictiveness. The success of the treatment relates to the patients comfort during this process. Patients are typically afraid of switching to a more suitable long-acting BZD (diazepam), and become stressed during the tapering and anxious from withdrawal symptoms. These obstacles could be overcome through individualized detoxification according to already published withdrawal schedules based on the administration of very precise diazepam doses in a long-term gradual tapering with possible addition of adjuvant drugs. Dose reduction does not change external appearance of the dosage form, and the patient could be treated until the placebo phase.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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