MRI findings induced by antipsychotic treatment and animal models of schizophrenia-like pathology

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877922" target="_blank" >RIV/62157124:16370/19:43877922 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
MRI findings induced by antipsychotic treatment and animal models of schizophrenia-like pathology
Original language description
Schizophrenia (SCZ) is a debilitating mental illness resulting in multiple structural and functional brain changes. We used Arterial Spin Labelling MRI technique in all studies to evaluate cerebral blood perfusion in SCZ-related brain regions using Bruker BioSpec 94/30 scanner. Study 1 was focused on the effect of acute and chronic olanzapine exposure. The aim of Study 2 was the evaluation of blood brain perfusion in two animal models of the SCZ-like phenotype. Study 3 was focused on the evaluation of cerebral blood perfusion in the well validated poly(I:C) model of SCZ in Wistar rats taking into account sex-dependent effects and the effect of aripiprazole treatment.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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