Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16810%2F21%3A43879175" target="_blank" >RIV/62157124:16810/21:43879175 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/21:43879175

Result on the web

<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000667835900001" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000667835900001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells10061291" target="_blank" >10.3390/cells10061291</a>

Result language

angličtina

Original language name

Innate and Adaptive Immune Genes Associated with MERS-CoV Infection in Dromedaries

Original language description

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

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UT code for WoS article

000667835900001

EID of the result in the Scopus database

2-s2.0-85107402321