Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F14%3A50002644" target="_blank" >RIV/62690094:18450/14:50002644 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellsig.2014.09.013" target="_blank" >http://dx.doi.org/10.1016/j.cellsig.2014.09.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellsig.2014.09.013" target="_blank" >10.1016/j.cellsig.2014.09.013</a>

Result language
angličtina
Original language name
Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival
Original language description
T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation ofMAPK pathway. The JAK/STAT pathway has recently been shown to be downstream targets of trichothecenes. However,whether there is any crosstalk between JNK and JAK/STAT pathways in trichothecene toxicity has not been studied. In the present study, we explored this potential in RAW264.7 cells treatedwith T-2 toxin. Our results revealed a crosstalk between JNK1 andSTAT3 after T-2 toxin treatment,which was mediated by K-Ras. T-2 toxin treatment resulted in rapid phosphorylation, and more importantly, JNK1- STAT3 signaling pathway was shown to maintain the normal function of the mitochondria and to inhibit T-2 toxin-induced apoptosis. Therefore, this pathway was considered to be a potential cell survival pathway. Breakdown and degranulation of ribosomes in the rough endoplasmic reticulum and swelling of mitochondria were clearly visible after the ce
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)