Kinetic and physicochemical analysis of structurally different bis-pyridinium oximes against pesticide inhibited AChE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50003339" target="_blank" >RIV/62690094:18470/15:50003339 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10290125
Result on the web
<a href="http://nopr.niscair.res.in/handle/123456789/30347" target="_blank" >http://nopr.niscair.res.in/handle/123456789/30347</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Kinetic and physicochemical analysis of structurally different bis-pyridinium oximes against pesticide inhibited AChE
Original language description
Physicochemical properties such as acid dissociation constant, pK(a), and lipophilicity, log P, of some bis-pyridinium monooximes with varying functionalities in the second pyridinium ring of the reactivator have been evaluated spectrophotometrically. Invitro reactivation kinetics of the investigated oximes against paraoxon inhibited electric eel AChE has been carried out. The studied oximes have pK(a) values within the range of 7.85-8.38 and negative log P values, exhibiting their low lipophilic character. Further, on the basis of reactivation parameters (k(r), K-D, k(r2)) the efficacy of bis-pyridinium monooximes has been explained.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Indian journal of chemistry section A-inorganic bio-inorganic physical theoretical and analytical chemistry
ISSN
0376-4710
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
1
Country of publishing house
IN - INDIA
Number of pages
6
Pages from-to
40-45
UT code for WoS article
000348245200005
EID of the result in the Scopus database
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