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A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F15%3A50003442" target="_blank" >RIV/62690094:18470/15:50003442 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/15:43875349 RIV/00216208:11160/15:10294117 RIV/00179906:_____/15:10294117

  • Result on the web

    <a href="http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=127660" target="_blank" >http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=127660</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/0929867322666150114163051" target="_blank" >10.2174/0929867322666150114163051</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A Direct Interaction Between Mitochondrial Proteins and Amyloid-beta Peptide and its Significance for the Progression and Treatment of Alzheimer's Disease

  • Original language description

    The amyloid-beta peptide (A beta) has been associated with Alzheimer's disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for A beta toxicity. Later, this hypothesis has been updated and soluble intracellular A beta forms and their effects within the cell have come into focus. Mitochondrial dysfunction plays an important role in the pathophysiology of AD. A beta was detected inside mitochondria and several mitochondrial proteins were found to interact directly with A beta. Such interactions can affect a protein's function and cause damage to the mitochondria and finally to the whole cell. This review summarizes the current knowledge of mitochondrial proteins directly interacting with A beta and discusses their significance for the development of therapeutics in the treatment of AD.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LD14009" target="_blank" >LD14009: Synthesis of compounds affecting mitochondrial enzymes as potential drugs for Alzheimer disease</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current medicinal chemistry

  • ISSN

    0929-8673

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    30

  • Pages from-to

    1056-1085

  • UT code for WoS article

    000350477600002

  • EID of the result in the Scopus database