Mycotoxins as human carcinogens-the IARC Monographs classification

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F17%3A50005520" target="_blank" >RIV/62690094:18470/17:50005520 - isvavai.cz</a>

Alternative codes found

RIV/75010330:_____/17:00011688

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs12550-016-0265-7" target="_blank" >http://link.springer.com/article/10.1007%2Fs12550-016-0265-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12550-016-0265-7" target="_blank" >10.1007/s12550-016-0265-7</a>

Result language

angličtina

Original language name

Mycotoxins as human carcinogens-the IARC Monographs classification

Original language description

Humans are constantly exposed to mycotoxins (e.g. aflatoxins, ochratoxins), mainly via food intake of plant and animal origin. The health risks stemming from mycotoxins may result from their toxicity, in particular their carcinogenicity. In order to prevent these risks, the International Agency for Research on Cancer (IARC) in Lyon (France)-through its IARC Monographs programme-has performed the carcinogenic hazard assessment of some mycotoxins in humans, on the basis of epidemiological data, studies of cancer in experimental animals and mechanistic studies. The present article summarizes the carcinogenic hazard assessments of those mycotoxins, especially aflatoxins (aflatoxin B-1, B-2, G(1), G(2) and M-1), fumonisins (fumonisin B-1 and B-2) and ochratoxin A (OTA). New information regarding the genotoxicity of OTA (formation of OTA-DNA adducts), the role of OTA in oxidative stress and the identification of epigenetic factors involved in OTA carcinogenesis-should they indeed provide strong evidence that OTA carcinogenicity is mediated by a mechanism that also operates in humans-could lead to the reclassification of OTA.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mycotoxin research

ISSN

0178-7888

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

65-73

UT code for WoS article

000392347800007

EID of the result in the Scopus database

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