The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014443" target="_blank" >RIV/62690094:18470/18:50014443 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/18:43889556 RIV/00179906:_____/18:10382555
Result on the web
<a href="http://dx.doi.org/10.1186/s40360-018-0227-0" target="_blank" >http://dx.doi.org/10.1186/s40360-018-0227-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40360-018-0227-0" target="_blank" >10.1186/s40360-018-0227-0</a>
Alternative languages
Result language
angličtina
Original language name
The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats
Original language description
Background: The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal treatment involving single oxime (HI-6) and atropin using in vivo methods. Methods: Brain damage and neuroprotective effects of antidotal treatment were evaluated in rats poisoned with sarin at a sublethal dose (108 mu g/kg i.m.; 90% LD50) using histopathological, Fluoro-Jade B and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis 24 h after sarin administration. Results: Both combinations of oximes reduce the number of rats that died before the end of experiment compared to non-treated sarin poisoning and sarin poisoning treated with HI-6 and atropine. In the case of treatment of sarin poisoning with HI-6 in combination with K203, all rats survived till the end of experiment. HI-6 with atropine was able to reduce sarin-induced brain damage, however, both combinations were slightly more effective. Conclusions: The oxime HI-6 in combination with K203 and atropine seems to be the most effective. Thus, both tested oxime combinations bring a small benefit in elimination of acute sarin-induced brain damage compared to single oxime antidotal therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC pharmacology and toxicology
ISSN
2050-6511
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
Jun
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000436965700001
EID of the result in the Scopus database
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