Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50015659" target="_blank" >RIV/62690094:18470/19:50015659 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0009279719302972?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279719302972?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2019.05.034" target="_blank" >10.1016/j.cbi.2019.05.034</a>

Result language
angličtina
Original language name
Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
Original language description
DDVP-inhibited rat diaphragm AChE reactivation by oxime K027/K203 was dose-dependent. Dose-response relationships were described by 4-parameter exponential and Hill models. Maximum size of DDVP-inhibited AChE reactivation by K-oximes was 2.1-fold. Oxime K027 had 5-fold higher relative reactivating potency compared to oxime K203.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology

Project
<a href="/en/project/GA18-01734S" target="_blank" >GA18-01734S: Butyrylcholinesterase reactivators for preparation of pseudo-catalytic scavengers applicable for organophosphorus intoxications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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