Antimicrobial Peptides: Amphibian Host Defense Peptides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50016123" target="_blank" >RIV/62690094:18470/19:50016123 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12110/19:43897803 RIV/00179906:_____/19:10403235
Result on the web
<a href="https://www.ingentaconnect.com/content/ben/cmc/2019/00000026/00000032/art00004;jsessionid=25nq1j1k6ii4n.x-ic-live-01" target="_blank" >https://www.ingentaconnect.com/content/ben/cmc/2019/00000026/00000032/art00004;jsessionid=25nq1j1k6ii4n.x-ic-live-01</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867325666180713125314" target="_blank" >10.2174/0929867325666180713125314</a>
Alternative languages
Result language
angličtina
Original language name
Antimicrobial Peptides: Amphibian Host Defense Peptides
Original language description
Antimicrobial Peptides (AMPs) are one of the most common components of the innate immune system that protect multicellular organisms against microbial invasion. The vast majority of AMPs are isolated from the frog skin. Anuran (frogs and toads) skin contains abundant AMPs that can be developed therapeutically. Such peptides are a unique but diverse group of molecules. In general, more than 50% of the amino acid residues form the hydrophobic part of the molecule. Normally, there are no conserved structural motifs responsible for activity, although the vast majority of the AMPs are cationic due to the presence of multiple lysine residues; this cationicity has a close relationship with antibacterial activity. Notably, recent evidence suggests that synthesis of AMPs in frog skin may confer an advantage on a particular species, although they are not essential for survival. Frog skin AMPs exert potent activity against antibiotic-resistant bacteria, protozoa, yeasts, and fungi by permeating and destroying the plasma membrane and inactivating intracellular targets. Importantly, since they do not bind to a specific receptor, AMPs are less likely to induce resistance mechanisms. Currently, the best known amphibian AMPs are esculentins, brevinins, ranacyclins, ranatuerins, nigrocin-2, magainins, dermaseptins, bombinins, temporins, and japonicins-1 and -2, and palustrin-2. This review focuses on these frog skin AMPs and the mechanisms underlying their antimicrobial activity. We hope that this review will provide further information that will facilitate further study of AMPs and cast new light on novel and safer microbicides.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current medicinal chemistry
ISSN
0929-8673
e-ISSN
—
Volume of the periodical
26
Issue of the periodical within the volume
32
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
23
Pages from-to
5924-5946
UT code for WoS article
000497819700003
EID of the result in the Scopus database
2-s2.0-85075676552