Pyridostigmine bromide and its relation to Gulf War illness
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50016831" target="_blank" >RIV/62690094:18470/20:50016831 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/20:00555792 RIV/00216208:11150/20:10418100 RIV/00179906:_____/20:10418100
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/15569543.2018.1480496" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15569543.2018.1480496</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15569543.2018.1480496" target="_blank" >10.1080/15569543.2018.1480496</a>
Alternative languages
Result language
angličtina
Original language name
Pyridostigmine bromide and its relation to Gulf War illness
Original language description
Pyridostigmine bromide acts as a reversible cholinesterase inhibitor that is used at relatively high doses in treatment of Myasthenia gravis and in low dose regimens as prophylaxis against nerve agents poisoning during the Gulf War. The manifestation of late nonspecific symptoms commonly called Gulf War illness has led to the discussion about the role of pyridostigmine bromide in the pathogenesis of this illness. In our study, we described plasma absorption profile of pyridostigmine bromide after p.o. administration in rats; subsequently, changes in blood biochemical and oxidative stress markers were measured. Pyridostigmine bromide was applied p.o. at the dose of 5.82 mg/kg b.w. according to the previously published recommendations. The absorption of pyridostigmine was relatively fast; the C-max in plasma was 110.20 +/- 15.12 ng/ml at T-max of 197.12 +/- 17.14 min. The bioavailability expressed as AUC(total) was 44,348 +/- 7608 min ng/ml. The prolongation of pyridostigmine in circulation is in agreement with relatively long half-life that was 179.00 +/- 28.54 min. Several blood biochemical markers were altered, including glucose, creatinine, creatine kinase, alanine aminotransferase, aspartate aminotransferase, interleukin-6, triglycerides, and cholesterol. However, the changes could be considered as mild. Thiobarbituric acid reactive substances and ferric reducing ability of plasma indicate suppression of basal metabolism. The results of blood biochemical and oxidative stress markers imply that long-term use might possibly change the basal metabolism and cause cellular damage with inflammatory changes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxin Reviews
ISSN
1556-9543
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
138-146
UT code for WoS article
000532601200005
EID of the result in the Scopus database
2-s2.0-85049578171