Current Anti-Inflammatory Therapies and the Potential of Secretory Phospholipase A(2) Inhibitors in the Design of New Anti-Inflammatory Drugs: A Review of 2012-2018
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50017122" target="_blank" >RIV/62690094:18470/20:50017122 - isvavai.cz</a>
Result on the web
<a href="https://www.ingentaconnect.com/content/ben/cmc/2020/00000027/00000003/art00010" target="_blank" >https://www.ingentaconnect.com/content/ben/cmc/2020/00000027/00000003/art00010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867326666190201120646" target="_blank" >10.2174/0929867326666190201120646</a>
Alternative languages
Result language
angličtina
Original language name
Current Anti-Inflammatory Therapies and the Potential of Secretory Phospholipase A(2) Inhibitors in the Design of New Anti-Inflammatory Drugs: A Review of 2012-2018
Original language description
The inflammatory process is a natural self-defense response of the organism to damage agents and its action mechanism involves a series of complex reactions. However, in some cases, this process can become chronic, causing much harm to the body. Therefore, over the years, many anti-inflammatory drugs have been developed aiming to decrease the concentrations of inflammatory mediators in the organism, which is a way of controlling these abnormal chain reactions. The main target of conventional anti-inflammatory drugs is the cyclooxygenase (COX) enzyme, but its use implies several side effects. Thus, based on these limitations, many studies have been performed, aiming to create new drugs, with new action mechanisms. In this sense, the phospholipase A(2) (PLA(2)) enzymes stand out. Among all the existing isoforms, secretory PLA(2) is the major target for inhibitor development, since many studies have proven that this enzyme participates in various inflammatory conditions, such as cancer, Alzheimer and arthritis. Finally, for the purpose of developing anti-inflammatory drugs that are sPLA(2) inhibitors, many molecules have been designed. Accordingly, this work presents an overview of inflammatory processes and mediators, the current available anti-inflammatory drugs, and it briefly covers the PLA(2) enzymes, as well as the diverse structural array of the newest sPLA(2) inhibitors as a possible target for the production of new anti-inflammatory drugs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current medicinal chemistry
ISSN
0929-8673
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
3
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
21
Pages from-to
477-497
UT code for WoS article
000514833000009
EID of the result in the Scopus database
2-s2.0-85079557383