Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F20%3A50021373" target="_blank" >RIV/62690094:18470/20:50021373 - isvavai.cz</a>
Result on the web
<a href="https://www.eurekaselect.com/article/101419" target="_blank" >https://www.eurekaselect.com/article/101419</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557519666191014142448" target="_blank" >10.2174/1389557519666191014142448</a>

Result language
angličtina
Original language name
Synthesis and Biological Activity of Hydrazones and Derivatives: A Review
Original language description
Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer's, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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