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The role of hypoxia-inducible factor 1 in tumor immune evasion

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50017464" target="_blank" >RIV/62690094:18470/21:50017464 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26620/21:PU138468 RIV/62156489:43210/21:43919004

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/med.21771" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/med.21771</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/med.21771" target="_blank" >10.1002/med.21771</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of hypoxia-inducible factor 1 in tumor immune evasion

  • Original language description

    Hypoxia-inducible factor 1 (HIF-1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF-1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion. In innate and adaptive immune systems, malignant tumor cells avoid their recognition and destruction by HIF-1. Tumor immune evasion allows cancer cells to proliferate and metastasize and is associated with immunotherapy failure and chemoresistance. In the hypoxic tumor microenvironment, HIF-1 signaling suppresses the innate and adaptive immune systems to evade immune attack by inducing the expression of immunosuppressive factors and immune checkpoint molecules, including vascular endothelial growth factor, prostaglandin E2, and programmed death-ligand 1/programmed death-1. Moreover, HIF-1 blocks tumor-associated antigen presentation via major histocompatibility complex class I chain-related/natural killer group 2, member D signaling. Tumor-associated autophagy and the release of tumor-derived exosomes contribute to HIF-1-mediated immune evasion. This review focuses on recent findings on the potential mechanism(s) underlying the effect of hypoxia and HIF-1 signaling on tumor immune evasion in the hypoxic tumor microenvironment. The effects of HIF-1 on immune checkpoint molecules, immunosuppressive molecules, autophagy, and exosomes have been described. Additionally, the potential role of HIF-1 in the regulation of tumor-derived exosomes, as well as the roles of HIF-1 and exosomes in tumor evasion, are discussed. This study will contribute to our understanding of HIF-1-mediated tumor immune evasion, leading to the development of effective HIF-1-targeting drugs and immunotherapies. © 2020 Wiley Periodicals LLC

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Medicinal Research Reviews

  • ISSN

    0198-6325

  • e-ISSN

  • Volume of the periodical

    41

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    22

  • Pages from-to

    1622-1643

  • UT code for WoS article

    000597314400001

  • EID of the result in the Scopus database

    2-s2.0-85097496277