The role of hypoxia-inducible factor 1 in tumor immune evasion

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50017464" target="_blank" >RIV/62690094:18470/21:50017464 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/21:PU138468 RIV/62156489:43210/21:43919004

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/med.21771" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/med.21771</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/med.21771" target="_blank" >10.1002/med.21771</a>

Result language

angličtina

Original language name

The role of hypoxia-inducible factor 1 in tumor immune evasion

Original language description

Hypoxia-inducible factor 1 (HIF-1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF-1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion. In innate and adaptive immune systems, malignant tumor cells avoid their recognition and destruction by HIF-1. Tumor immune evasion allows cancer cells to proliferate and metastasize and is associated with immunotherapy failure and chemoresistance. In the hypoxic tumor microenvironment, HIF-1 signaling suppresses the innate and adaptive immune systems to evade immune attack by inducing the expression of immunosuppressive factors and immune checkpoint molecules, including vascular endothelial growth factor, prostaglandin E2, and programmed death-ligand 1/programmed death-1. Moreover, HIF-1 blocks tumor-associated antigen presentation via major histocompatibility complex class I chain-related/natural killer group 2, member D signaling. Tumor-associated autophagy and the release of tumor-derived exosomes contribute to HIF-1-mediated immune evasion. This review focuses on recent findings on the potential mechanism(s) underlying the effect of hypoxia and HIF-1 signaling on tumor immune evasion in the hypoxic tumor microenvironment. The effects of HIF-1 on immune checkpoint molecules, immunosuppressive molecules, autophagy, and exosomes have been described. Additionally, the potential role of HIF-1 in the regulation of tumor-derived exosomes, as well as the roles of HIF-1 and exosomes in tumor evasion, are discussed. This study will contribute to our understanding of HIF-1-mediated tumor immune evasion, leading to the development of effective HIF-1-targeting drugs and immunotherapies. © 2020 Wiley Periodicals LLC

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30108 - Toxicology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Research Reviews

ISSN

0198-6325

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

22

Pages from-to

1622-1643

UT code for WoS article

000597314400001

EID of the result in the Scopus database

2-s2.0-85097496277