Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018008" target="_blank" >RIV/62690094:18470/21:50018008 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/21:10426041 RIV/00216208:11110/21:10426041 RIV/00179906:_____/21:10426041 RIV/00064165:_____/21:10426041 RIV/46747885:24530/21:00009681

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2021.514579/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2021.514579/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fpsyt.2021.514579" target="_blank" >10.3389/fpsyt.2021.514579</a>

Result language

angličtina

Original language name

Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia

Original language description

A core symptom that is frequently linked with dysregulation of glutamatergic neurotransmission in regard to schizophrenia is impairment or damage of executive functioning as a component of cognitive deficiency. The amino acid D-serine plays the role of an endogenous coagonist at the glutamatergic N-methyl-D-aspartate (NMDA) receptor glycine modulatory site. Considerably reduced serum levels of D-serine were found in patients suffering from schizophrenia compared with healthy control participants. An increase in D-serine led to augmented cognitive functionality in patients suffering from schizophrenia who were undergoing clinical trials and given the treatment of first- and second-generation antipsychotics. The study proposed the hypothesis that the D-serine blood serum levels may be linked with the extent of executive functionality in those suffering from the mental illness in question. For the purpose of examining executive function in such patients, the Rey–Osterrieth Complex Figure, Trail Making, and Wisconsin Card Sorting tests were applied (n = 50). High-performance liquid chromatography was used to gauge the total serine and D-serine levels. The extent of damage was examined through neuropsychological tests and was found to be considerably linked to D-serine serum level and the D-serine/total serine ratio (p &lt; 0.05) in the sample being considered. A lower average serum level of D-serine and lower D-serine/total serine ratio were observed in participants with the worst performance compared with those displaying the best performance—this was true when the patients were split into quartile groups based on their results (p &lt; 0.05). The findings of modified D-serine serum levels and the D-serine/total serine ratio linked to the extent of damage in executive functioning indicate that serine metabolism that is coresponsible for NMDA receptor dysfunction has been changed. © Copyright © 2021 Hons, Zirko, Vasatova, Doubek, Klimova, Masopust, Valis and Kuca.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Psychiatry

ISSN

1664-0640

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

March

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

"Article number 514579"

UT code for WoS article

000639120700001

EID of the result in the Scopus database

2-s2.0-85104014996