Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018984" target="_blank" >RIV/62690094:18470/21:50018984 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/21:00556874 RIV/00179906:_____/21:10434138 RIV/00216208:11160/21:10434138 RIV/00216224:14160/21:00122469
Result on the web
<a href="https://www.mdpi.com/1420-3049/26/5/1279" target="_blank" >https://www.mdpi.com/1420-3049/26/5/1279</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules26051279" target="_blank" >10.3390/molecules26051279</a>
Alternative languages
Result language
angličtina
Original language name
Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids
Original language description
Two new minor Amaryllidaceae alkaloids were isolated from Hippeastrum x hybridum cv. Ferrari and Narcissus pseudonarcissus cv. Carlton. The chemical structures were identified by various spectroscopic (one- and two-dimensional (1D and 2D) NMR, circular dichroism (CD), high-resolution mass spectrometry (HRMS) and by comparison with literature data of similar compounds. Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 +/- 0.73 mu M for hAChE and 3.44 +/- 0.02 mu M for hBuChE. The accommodation of 2 into the active sites of respective enzymes was predicted using molecular modeling simulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOLECULES
ISSN
1420-3049
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
"Article Number: 1279"
UT code for WoS article
000628415800001
EID of the result in the Scopus database
2-s2.0-85102323739