A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019084" target="_blank" >RIV/62690094:18470/22:50019084 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25310/22:39918820 RIV/00216208:11150/22:10443716 RIV/00179906:_____/22:10443716
Result on the web
<a href="https://www.mdpi.com/2073-4360/14/5/938" target="_blank" >https://www.mdpi.com/2073-4360/14/5/938</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/polym14050938" target="_blank" >10.3390/polym14050938</a>
Alternative languages
Result language
angličtina
Original language name
A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation
Original language description
Biodegradable biliary stents are promising treatments for biliary benign stenoses. One of the materials considered for their production is polydioxanone (PPDX), which could exhibit a suitable degradation time for use in biodegradable stents. Proper material degradation characteristics, such as sufficient stiffness and disintegration resistance maintained for a clinically relevant period, are necessary to ensure stent safety and efficacy. The hydrolytic degradation of commercially available polydioxanone biliary stents (ELLA-CS, Hradec Kralove, Czech Republic) in phosphate-buffered saline (PBS) was studied. During 9 weeks of degradation, structural, physical, and surface changes were monitored using Raman spectroscopy, differential scanning calorimetry, scanning electron microscopy, and tensile and torsion tests. It was found that the changes in mechanical properties are related to the increase in the ratio of amorphous to crystalline phase, the so-called amorphicity. Monitoring the amorphicity using Raman spectroscopy has proven to be an appropriate method to assess polydioxanone biliary stent degradation. At the 1732 cm(-1) Raman peak, the normalized shoulder area is less than 9 cm(-1) which indicates stent disintegration. The stent disintegration started after 9 weeks of degradation in PBS, which agrees with previous in vitro studies on polydioxanone materials as well as with in vivo studies on polydioxanone biliary stents.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/LM2018103" target="_blank" >LM2018103: Center of Materials and Nanotechnologies - Research Infrastructure</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
POLYMERS
ISSN
2073-4360
e-ISSN
2073-4360
Volume of the periodical
14
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
"Article Number: 938"
UT code for WoS article
000768929700001
EID of the result in the Scopus database
2-s2.0-85125580279