In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents’ surrogates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50020597" target="_blank" >RIV/62690094:18470/23:50020597 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0009279723003459?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279723003459?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2023.110678" target="_blank" >10.1016/j.cbi.2023.110678</a>
Alternative languages
Result language
angličtina
Original language name
In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents’ surrogates
Original language description
Nerve agents (NA) pose as a great risk in the modern world. NA from the V-series, such as VX, are currently recognized as the most toxic among those compounds. However, the emergence of new classes of toxicants recently included in the Chemical Weapons Convention (CWC), such as the A-series NA, a class of organophosphorus compounds related to phosphoramidates, pose a new source of concern due to the lack of information. In order advance in the investigation on the toxicity of such toxic chemicals, we performed in vitro studies to compare representatives of the V- and A-series using affordable surrogates. Results suggest a similar inhibition potency between both agents. © 2023 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemico-biological interactions
ISSN
0009-2797
e-ISSN
1872-7786
Volume of the periodical
383
Issue of the periodical within the volume
September
Country of publishing house
IE - IRELAND
Number of pages
4
Pages from-to
"Article number: 110678"
UT code for WoS article
001106780500001
EID of the result in the Scopus database
2-s2.0-85167970991