Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50020648" target="_blank" >RIV/62690094:18470/23:50020648 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/23:10469470
Result on the web
<a href="https://link.springer.com/article/10.1007/s00204-023-03587-0" target="_blank" >https://link.springer.com/article/10.1007/s00204-023-03587-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00204-023-03587-0" target="_blank" >10.1007/s00204-023-03587-0</a>
Alternative languages
Result language
angličtina
Original language name
Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
Original language description
Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic organophosphate poisoning. They are effective nucleophiles that can restore the catalytic activity of acetylcholinesterase; however, their main limitation is the difficulty in crossing the blood-brain barrier (BBB) because of their strongly hydrophilic nature. Various approaches to overcome this limitation and enhance the bioavailability of oxime reactivators in the CNS have been evaluated; these include structural modifications, conjugation with molecules that have transporters in the BBB, bypassing the BBB through intranasal delivery, and inhibition of BBB efflux transporters. A promising approach is the use of nanoparticles (NPs) as the delivery systems. Studies using mesoporous silica nanomaterials, poly (l-lysine)-graft-poly(ethylene oxide) NPs, metallic organic frameworks, poly(lactic-co-glycolic acid) NPs, human serum albumin NPs, liposomes, solid lipid NPs, and cucurbiturils, have shown promising results. Some NPs are considered as nanoreactors for organophosphate detoxification; these combine bioscavengers with encapsulated oximes. This study provides an overview and critical discussion of the strategies used to enhance the bioavailability of oxime reactivators in the central nervous system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of toxicology
ISSN
0340-5761
e-ISSN
1432-0738
Volume of the periodical
97
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
22
Pages from-to
2839-2860
UT code for WoS article
001060679200001
EID of the result in the Scopus database
2-s2.0-85168916093