Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F24%3A50021580" target="_blank" >RIV/62690094:18470/24:50021580 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/24:10481996
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0045206824004310?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0045206824004310?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioorg.2024.107526" target="_blank" >10.1016/j.bioorg.2024.107526</a>

Result language
angličtina
Original language name
Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds
Original language description
In this review, the current progress in the research and development of butyrylcholinesterase (BChE) reactivators is summarised and the advantages or disadvantages of these reactivators are critically discussed. Organophosphorus compounds such as nerve agents (sarin, tabun, VX) or pesticides (chlorpyrifos, diazinon) cause irreversible inhibition of acetylcholinesterase (AChE) and BChE in the human body. While AChE inhibition can be life threatening due to cholinergic overstimulation and crisis, selective BChE inhibition has presumably no adverse effects. Because BChE is mostly found in plasma, its activity is important for the scavenging of organophosphates before they can reach AChE in the central nervous system. Therefore, this enzyme in combination with its reactivator can be used as a pseudo-catalytic scavenger of organophosphates. Three structural types of BChE reactivators were found, i.e. bisquaternary salts, monoquaternary salts and uncharged compounds. Although the reviewed reactivators have certain limitations, the promising candidates for BChE reactivation were found in each structural group.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30108 - Toxicology

Project
<a href="/en/project/GA22-14568S" target="_blank" >GA22-14568S: Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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