Pretreatment Plasma Folate Modulates the Pharmacodynamic Effect of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma: ?Folate Overrescue? Concept Revisited
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F06%3A%230000066" target="_blank" >RIV/65269705:_____/06:#0000066 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pretreatment Plasma Folate Modulates the Pharmacodynamic Effect of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma: ?Folate Overrescue? Concept Revisited
Original language description
To evaluate the influence of pretreatment plasma folate concentrations on methotrexate exposure in children with acute lymphoblastic leukemia/non-Hodgkin lymphoma treated with high-dose methotrexate, we assessed time profiles of plasma homocysteine, folate, and vitamin B12 concentrations in children treated with highdose methotrexate with leucovorin rescue. We analyzed 98 treatment courses. The study endpoints were to determine how methotrexate exposure is related to homocysteine accumulation and whether it is influenced by pretreatment plasma folate. Results: Peak concentrations of homocysteine increased from the start of the intravenous infusion through cessation of methotrexate therapy up to time point t42, when this trend was reversed by administration of folinic acid.
Czech name
Hladina folátu před podáním MTX ovlivňuje farmakodynamický efekt vysoce dávkovaného metothrexátu u dětí s ALL A NHL. Oživení konceptu overresce.
Czech description
Hladina endogenního folátu před aplikací HD-MTX ovlivňuje farmakodynamický efekt antifolátové terapie. Zásadní, statisticky signifikantní je efekt hladiny plasmatického folátu před vlastním podáním MTX u dětí a ALL či NHL.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR8448" target="_blank" >NR8448: Characterization of leukemia cell gene expression using DNA microarrays and its utilization for molecular diagnostics and therapy response prediction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical chemistry
ISSN
0009-9147
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
692-700
UT code for WoS article
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EID of the result in the Scopus database
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