Prognostic impact of p53 aberrations for R-CHOP-treated patiens with difuse large B-cell Lymphoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001221" target="_blank" >RIV/65269705:_____/11:#0001221 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3892/ijo.2011.1170" target="_blank" >http://dx.doi.org/10.3892/ijo.2011.1170</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijo.2011.1170" target="_blank" >10.3892/ijo.2011.1170</a>

Result language

angličtina

Original language name

Prognostic impact of p53 aberrations for R-CHOP-treated patiens with difuse large B-cell Lymphoma

Original language description

We performed complex analysis of the p53 tumor suppressor in collection of 75 DLBCL cases. Fifty four patients were de novo cases, twenty one cases developed into DLBCL by transformation from less aggressive disease. We determined functional status by analysis of separated alleles in yeast (FASAY) and analyzed the p53 mutations by cDNA sequencing. We assessed the level of the p53 protein by immunoblotting analysis. We used FISH to analyze loss of the p53 and ATM (ataxia telangiectasia mutated) genes deletion. We detected 16 p53 mutations (21.3%) including the mutation activating nonsense-mediated RNA decay pathway. Deletion of the p53 allele was more common in cases with p53 mutation. Mutations and/or deletions of p53 had statistically significant negative impact on progression-free survival and tended to decrease also overall survival in 46 de novo DLBCL patients treated with R-CHOP. p53 aberrations are negative predictors for survival of DLBCL patients treated with R-CHOP.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Oncology

ISSN

1019-6439

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

6

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

1413-1420

UT code for WoS article

000296315400009

EID of the result in the Scopus database

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