All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Prognostic impact of p53 aberrations for R-CHOP-treated patiens with difuse large B-cell Lymphoma

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001221" target="_blank" >RIV/65269705:_____/11:#0001221 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3892/ijo.2011.1170" target="_blank" >http://dx.doi.org/10.3892/ijo.2011.1170</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3892/ijo.2011.1170" target="_blank" >10.3892/ijo.2011.1170</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prognostic impact of p53 aberrations for R-CHOP-treated patiens with difuse large B-cell Lymphoma

  • Original language description

    We performed complex analysis of the p53 tumor suppressor in collection of 75 DLBCL cases. Fifty four patients were de novo cases, twenty one cases developed into DLBCL by transformation from less aggressive disease. We determined functional status by analysis of separated alleles in yeast (FASAY) and analyzed the p53 mutations by cDNA sequencing. We assessed the level of the p53 protein by immunoblotting analysis. We used FISH to analyze loss of the p53 and ATM (ataxia telangiectasia mutated) genes deletion. We detected 16 p53 mutations (21.3%) including the mutation activating nonsense-mediated RNA decay pathway. Deletion of the p53 allele was more common in cases with p53 mutation. Mutations and/or deletions of p53 had statistically significant negative impact on progression-free survival and tended to decrease also overall survival in 46 de novo DLBCL patients treated with R-CHOP. p53 aberrations are negative predictors for survival of DLBCL patients treated with R-CHOP.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Oncology

  • ISSN

    1019-6439

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GR - GREECE

  • Number of pages

    8

  • Pages from-to

    1413-1420

  • UT code for WoS article

    000296315400009

  • EID of the result in the Scopus database