Plerixafor to rescue failing chemotherapy - based stem cell mobilization: it's not too lat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001503" target="_blank" >RIV/65269705:_____/11:#0001503 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10428194.2011.578312" target="_blank" >http://dx.doi.org/10.3109/10428194.2011.578312</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2011.578312" target="_blank" >10.3109/10428194.2011.578312</a>
Alternative languages
Result language
angličtina
Original language name
Plerixafor to rescue failing chemotherapy - based stem cell mobilization: it's not too lat
Original language description
Plerixafor can rescue the outcome of failing chemotherapy-based stem cell mobilization. However, the optimal time for plerixafor injection in this setting has not been determined. This was investigated by retrospective analysis of data from 48 mobilizations with plerixafor, chemotherapy, and granulocyte-colony stimulating factor (G-CSF). The required yield of 2.0 x 10(6) CD34+ cells/kg was collected from 71% of patients; the median total yield was 4.1 x 10(6) CD34+ cells/kg. Patients to whom plerixaforwas administered late (>= 15 days) after chemotherapy, after a long duration (>= 13 days) of treatment with G-CSF, or when the white blood cell count was high (>= 20 x 10(9)/L) were mobilized as efficiently as other patients. Plerixafor was shown to rescue mobilizations at a comparable rate in patients with critically low levels of peripheral blood CD34+ cells (<3/microL) and those with higher concentrations. These data suggest that late administration of plerixafor in the course of chem
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia & Lymphoma
ISSN
1042-8194
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1711-1719
UT code for WoS article
000294228100016
EID of the result in the Scopus database
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