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Plerixafor to rescue failing chemotherapy - based stem cell mobilization: it's not too lat

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001503" target="_blank" >RIV/65269705:_____/11:#0001503 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3109/10428194.2011.578312" target="_blank" >http://dx.doi.org/10.3109/10428194.2011.578312</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/10428194.2011.578312" target="_blank" >10.3109/10428194.2011.578312</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plerixafor to rescue failing chemotherapy - based stem cell mobilization: it's not too lat

  • Original language description

    Plerixafor can rescue the outcome of failing chemotherapy-based stem cell mobilization. However, the optimal time for plerixafor injection in this setting has not been determined. This was investigated by retrospective analysis of data from 48 mobilizations with plerixafor, chemotherapy, and granulocyte-colony stimulating factor (G-CSF). The required yield of 2.0 x 10(6) CD34+ cells/kg was collected from 71% of patients; the median total yield was 4.1 x 10(6) CD34+ cells/kg. Patients to whom plerixaforwas administered late (>= 15 days) after chemotherapy, after a long duration (>= 13 days) of treatment with G-CSF, or when the white blood cell count was high (>= 20 x 10(9)/L) were mobilized as efficiently as other patients. Plerixafor was shown to rescue mobilizations at a comparable rate in patients with critically low levels of peripheral blood CD34+ cells (<3/microL) and those with higher concentrations. These data suggest that late administration of plerixafor in the course of chem

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia & Lymphoma

  • ISSN

    1042-8194

  • e-ISSN

  • Volume of the periodical

    52

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    1711-1719

  • UT code for WoS article

    000294228100016

  • EID of the result in the Scopus database