Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001582" target="_blank" >RIV/65269705:_____/11:#0001582 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14330/11:00051519
Result on the web
<a href="http://dx.doi.org/10.1016/j.clim.2010.09.007" target="_blank" >http://dx.doi.org/10.1016/j.clim.2010.09.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clim.2010.09.007" target="_blank" >10.1016/j.clim.2010.09.007</a>

Result language
angličtina
Original language name
Multiple myeloma patients at peripheral blood stem cell harvest: restricted usage of TCR beta variable families
Original language description
The immune systems of multiple myeloma patients are suppressed by the disease itself, and this immunosuppression is further enhanced by standard therapies. The aim of our study was to evaluate the effects of initial chemotherapy and a peripheral blood mobilisation regimen on T-cell population diversity. Reverse transcription polymerase chain reaction (RT-PCR) with a new set of primers, in combination with capillary electrophoresis, was established. The methodology was used to analyse the relative expression of 27 T-cell receptor beta variable gene families (BV families) in multiple myeloma patients undergoing peripheral blood stem cell harvest. We found that the overall BV family usage in these patients was restricted; the relative expression of 10 BVfamilies was significantly depressed in patients compared to healthy donors. These findings demonstrate that the preparative regimen for autologous stem cell transplantation affects the T-cell population in terms of the restriction of its
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)