ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001654" target="_blank" >RIV/65269705:_____/12:#0001654 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00060752
Result on the web
<a href="http://dx.doi.org/10.1038/leu.2012.25" target="_blank" >http://dx.doi.org/10.1038/leu.2012.25</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/leu.2012.25" target="_blank" >10.1038/leu.2012.25</a>
Alternative languages
Result language
angličtina
Original language name
ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia
Original language description
Recent evidence suggests that - in addition to 17p deletion - TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data from retrospective analyses and prospective clinical trials show that ~5% of untreated CLL patients with treatment indication have a TP53 mutation in the absence of 17p deletion. These patients have a poor response and reduced progression-free survival and overall survival with standard treatment approaches. These data suggest that TP53 mutation testing warrants integration into current diagnostic work up of patients with CLL. There are a number of assays to detect TP53 mutations, which have respective advantages and shortcomings. Direct Sanger sequencing of exons 4-9 can be recommended as a suitable test to identify TP53 mutations for centers with limited experience with alternative screening methods. Recommendations are provided on standard operating procedures, quality control, reporting and interpretation. Patients with treatmen
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
1458-1461
UT code for WoS article
000306307600003
EID of the result in the Scopus database
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