Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F15%3A00063654" target="_blank" >RIV/65269705:_____/15:00063654 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/15:00084906

Result on the web

<a href="http://www.tandfonline.com/doi/full/10.1586/17474086.2015.1079123" target="_blank" >http://www.tandfonline.com/doi/full/10.1586/17474086.2015.1079123</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1586/17474086.2015.1079123" target="_blank" >10.1586/17474086.2015.1079123</a>

Result language

angličtina

Original language name

Treatment of chronic lymphocytic leukemia with monoclonal antibodies, where are we heading?

Original language description

Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the western world and monoclonal antibodies (mAbs) are important part of CLL treatment. The goal of this article was to summarize current literature on the position of mAbs in CLL treatment and to mention factors influencing effectiveness of mAbs in CLL. Several new mAbs have been developed and investigated in CLL over the past few years. Mainly anti-CD20 monoclonal antibodies are still used routinely in CLL therapy. Unfortunately, the clinical application of mAbs needs to be further improved. Novel combinations and sequences of mAbs with other compounds need to be studied in clinical trials in order to increase overall response rate and prolong remission duration. Mechanisms of action of mAbs or mechanisms of resistance to mAbs have to be also investigated to predict effectiveness of mAb in particular patient.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Expert Review of Hematology

ISSN

1747-4086

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

22

Pages from-to

743-764

UT code for WoS article

000365125800002

EID of the result in the Scopus database

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