Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00064884" target="_blank" >RIV/65269705:_____/16:00064884 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/16:00089581

Result on the web

<a href="https://www.spandidos-publications.com/10.3892/or.2016.4658" target="_blank" >https://www.spandidos-publications.com/10.3892/or.2016.4658</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2016.4658" target="_blank" >10.3892/or.2016.4658</a>

Result language

angličtina

Original language name

Expression of D-type cyclins in mantle cell and diffuse large B-cell lymphomas

Original language description

D-type cyclins are involved in cell cycle regulation and play an important role in the pathogenesis of lymphomas. Aberrant expression of cyclin D1 is associated with mantle cell lymphoma (MCL) and serves as a diagnostic marker of MCL. Analysis of cyclin D expression in tumor tissues of patients with diffuse large B-cell lymphoma (DLBCL) which comprises a heterogeneous group of tumors may contribute to their stratification. We analyzed expression of cyclin D1, D2, and D3 mRNAs in 30 MCL and 104 DLBCL patients using qRT-PCR and addressed their significance for disease outcome. We confirmed a high level of cyclin Dl mRNA in 29 MCL cases (97%). One case (3%) was identified as positive for cyclin D2. Expression of cyclin Dl was limited to MCL and did not occur in DLBCL. Overexpression of cyclin D2, which is rare in MCL, occurred more frequently in DLBCL (11 cases, 10.6%). We showed that high expression of cyclin D2 in DLBCL cases de novo decreased the overall survival rate (P=0.016) and progression-free survival (P=0.009). The expression pattern of cyclin D3 was similar in both types of studied lymphomas and it did not affect the disease outcome.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/NT13784" target="_blank" >NT13784: Complex analysis of p53 mutants in lymphoproliferative diseases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

5

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

2673-2680

UT code for WoS article

000374077700021

EID of the result in the Scopus database

—