Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065000" target="_blank" >RIV/65269705:_____/16:00065000 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00090072

Result on the web

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.150622" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2015.150622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7754/Clin.Lab.2015.150622" target="_blank" >10.7754/Clin.Lab.2015.150622</a>

Result language

angličtina

Original language name

Manganese in Whole Blood and Hair in Patients with Long-Term Home Parenteral Nutrition

Original language description

Background: Manganese is an essential trace element and indispensable component of nutrition mixtures in long-term home parenteral nutrition (HPN) of patients. On the other hand, neurotoxic effects of excess manganese in the organism have been known for a long time. The objective of the present study was to determine manganese concentration in whole blood and hair of patients with long-term home parenteral nutrition. Methods: We examined 16 patients (7 men and 9 women) aged from 28 to 68 years on long-term HPN lasting from 4 to 96 months. The short bowel syndrome was an indication for HPN. The daily dose of manganese ranged between 80 and 470 mu g/day (1.2 to 8.5 mu g/kg/day). Results: In the investigated patients we detected approximately a doubled value of manganese concentration in whole blood in comparison to the control group (16.2 mu g/L; 12.9 - 20.4 mu g/L and 7.4 mu g/L; 6.4 - 8.4 mu g/L). In five patients with symptoms of cholestatic hepatopathy, Mn concentration in whole blood exceeded the value of 20.0 mu g/L. Magnetic resonance of the brain in four of these patients detected a hyperintense T1-signal in the globus pallidus without any clinical symptoms similar to the Parkinson's syndrome. The content of manganese in the patients' hair was also significantly increased (p < 0.04). Conclusions: The results of our study corroborate the necessity of careful monitoring of the manganese concentration in the organism during HPN, especially in patients with liver disorders. Individualized HPN with greater accessibility of variable mixtures of trace elements would certainly be greatly beneficial, at least with regard to problems associated with manganese substitution.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Laboratory

ISSN

1433-6510

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

173-177

UT code for WoS article

000370463700021

EID of the result in the Scopus database

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