Thrombopoietin receptor is required for the oncogenic function of CALR mutants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065931" target="_blank" >RIV/65269705:_____/16:00065931 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00091729

Result on the web

<a href="http://www.nature.com/leu/journal/v30/n8/full/leu201632a.html" target="_blank" >http://www.nature.com/leu/journal/v30/n8/full/leu201632a.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2016.32" target="_blank" >10.1038/leu.2016.32</a>

Result language

angličtina

Original language name

Thrombopoietin receptor is required for the oncogenic function of CALR mutants

Original language description

Myeloproliferative neoplasms (MPNs) are diseases characterized by the pathologic expansion of myeloid cells of the hematopoietic lineage. The three 'classical' MPNs include polycythemia vera (PV, increase in erythrocytes), essential thrombocythemia (ET, increase in platelets) and primary myelofibrosis (PMF, usually elevated platelet counts associated with fibrotic deposition in the bone marrow).1 MPNs are essentially clonal diseases driven by somatic mutations in hematopoietic stem and progenitor cells. So far, three genes have been identified that can drive the disease phenotype when mutated.2 Activating mutations in Janus Kinase 2 (JAK2) and the thrombopoietin receptor (MPL) have been known for close to a decade and their mechanism of action has been extensively studied.3-8 Recently, we and others identified somatic mutations in the CALR gene in 25-35% of ET and PMF patients.9,10

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

—

Volume of the periodical

30

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1759-1763

UT code for WoS article

000380826400018

EID of the result in the Scopus database

—