Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00066944" target="_blank" >RIV/65269705:_____/17:00066944 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00096159

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/myc.12595/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/myc.12595/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/myc.12595" target="_blank" >10.1111/myc.12595</a>

Result language

angličtina

Original language name

Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry

Original language description

Saprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12-year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co-morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S.capitata (n=14), S.clavata (n=5), G.candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S.capitata and S.clavata isolates with the exception of one S.capitata (MIC 4mg/L) isolate had MICs&gt;32mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and &gt;32mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B +/- flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mycoses

ISSN

0933-7407

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

273-279

UT code for WoS article

000395433700009

EID of the result in the Scopus database

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