The Role of microRNA in Ischemic and Hemorrhagic Stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00067521" target="_blank" >RIV/65269705:_____/17:00067521 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00094602
Result on the web
<a href="http://dx.doi.org/10.2174/1567201813666160919142212" target="_blank" >http://dx.doi.org/10.2174/1567201813666160919142212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1567201813666160919142212" target="_blank" >10.2174/1567201813666160919142212</a>
Alternative languages
Result language
angličtina
Original language name
The Role of microRNA in Ischemic and Hemorrhagic Stroke
Original language description
Background: Stroke is the second leading cause of death worldwide. Understanding of gene expression dynamics could bring new approaches in diagnostics and therapy of stroke. Small noncoding molecules termed "microRNA" represent the most flexible network of gene expression regulators. Method: The aim of this review was to briefly describe the structure and function of microRNA and summarize the current knowledge about the involvement of microRNAs in the pathophysiology of ischemic and hemorrhagic stroke based on both experimental and clinical studies. Results: Numerous profiling studies identified candidate microRNAs and partially described dynamics of their expression after the stroke. However, complex associations of specific microRNAs expression with main clinical characteristics and deeper insight into mechanisms of their regulatory functions are still missing. In this review, we put special emphasis on several microRNA clusters involved in neuroprotection (miR-124, miR-181, miR-21, miR-29, miR-210 and let7). Potential application of microRNAs as biomarkers and diagnostic or therapeutic targets was also discussed. Conclusion: Full understanding of the regulatory mechanisms of the microRNA networks represents a novel direction for stroke research. To date, we do not have effective tools to control pathophysiological processes associated with stroke. Thus the microRNAs have to be considered as a very promising target for future stroke therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Drug Delivery
ISSN
1567-2018
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
6
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
16
Pages from-to
816-831
UT code for WoS article
000409883200010
EID of the result in the Scopus database
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