Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00068192" target="_blank" >RIV/65269705:_____/18:00068192 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00102140

Result on the web

<a href="http://www.nature.com/articles/leu2017274" target="_blank" >http://www.nature.com/articles/leu2017274</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/leu.2017.274" target="_blank" >10.1038/leu.2017.274</a>

Result language

angličtina

Original language name

Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL

Original language description

In our systematic study of CLL cases with multiple productive IGH rearrangements (MP-IGH CLL),3 we previously showed that one-third of them exhibit two CLL populations with distinct immunophenotypes. We also pointed to the presence of multiple clones as a likely cause of MP-IGH detection even in cases with an immunophenotypically monoclonal disease, on the basis of IGK, IGL and incomplete IGH gene rearrangement analyses. Still, the underlying biological cause of MP-IGHs possibly involves lack of allelic exclusion4 or IGHV gene replacement.5 The extent to which these mechanisms are involved in MP-IGH CLL cases with homogeneous immunophenotype is still not known, and the lack of conclusive evidence hinders further research on CLL oligoclonality. To clarify this phenomenon, we performed extensive analysis of clonality in MP-IGH CLL combining conventional methods (Sanger sequencing, IGH fragment analysis), immunophenotyping, single-cell analysis (SCA), and next-generation sequencing (NGS).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Leukemia

ISSN

0887-6924

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

234-236

UT code for WoS article

000419771800027

EID of the result in the Scopus database

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