Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00068522" target="_blank" >RIV/65269705:_____/18:00068522 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00102134
Result on the web
<a href="http://dx.doi.org/10.1080/14767058.2017.1323530" target="_blank" >http://dx.doi.org/10.1080/14767058.2017.1323530</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14767058.2017.1323530" target="_blank" >10.1080/14767058.2017.1323530</a>

Result language
angličtina
Original language name
Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
Original language description
Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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