Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00068781" target="_blank" >RIV/65269705:_____/18:00068781 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00103657

Result on the web

<a href="http://dx.doi.org/10.1007/s00392-017-1173-3" target="_blank" >http://dx.doi.org/10.1007/s00392-017-1173-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00392-017-1173-3" target="_blank" >10.1007/s00392-017-1173-3</a>

Result language

angličtina

Original language name

Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications

Original language description

Background The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown. Methods Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes. Results Positive and negative linear relationships between 90-day mortality and sK+ above 4.5 mmol/L (hyperkalemia) and below 3.5 mmol/L (hypo-kalemia) were observed. Hazard ratio for death was 1.46 [1.34-1.58] for hyperkalemia and 1.22 [1.06-1.40] for hypokalemia. In a fully adjusted model, only hyperkalemia remained associated with mortality (HR 1.03 [1.02-1.04] for each 0.1 mmol/l change of sK+ above 4.5 mmol/L). Interaction tests revealed that the association between hyperkalemia and outcome was significantly affected by chronic medications. The association between hyperkalemia and mortality was absent for patients treated with beta blockers and in those with preserved renal function. Conclusions In patients with AHF, sK+ &gt; 4.5 mmol/L appears to be associated with 90-day mortality. B-blockers have potentially a protective effect in the setting of hyperkalemia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Research in Cardiology

ISSN

1861-0684

e-ISSN

—

Volume of the periodical

107

Issue of the periodical within the volume

3

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

214-221

UT code for WoS article

000425730100003

EID of the result in the Scopus database

2-s2.0-85032362885