Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069079" target="_blank" >RIV/65269705:_____/18:00069079 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104901

Result on the web

<a href="https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2018.0033/46674" target="_blank" >https://journals.viamedica.pl/cardiology_journal/article/view/CJ.a2018.0033/46674</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/CJ.a2018.0033" target="_blank" >10.5603/CJ.a2018.0033</a>

Result language

angličtina

Original language name

Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Original language description

Background: While prolongation of QRS duration and QTc interval during acute myocardial infarction (AMI) has been reported in animals, limited data is available for these readily available electrocardiography (ECG) markers in humans. Methods: Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected AMI in a prospective diagnostic multicentre study were prospectively assessed, Digital 12-lead ECGs were recorded at presentation. QRS duration and QTc interval were automatically calculated in a blinded fashion. Final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results: Among 4042 patients, AMI was the final diagnosis in 19% of patients. Median QRS duration and median QTc interval were significantly greater in patients with AMI compared to those with other final diagnoses (98 ms (IQR 88-108] vs. 94 ms [IQR 86-102] and 436 ms [IQR 414-462] vs. 425 ms [IQR 407-445], p &lt; 0.001 for both comparisons). The diagnostic value of both ECG signatures however was only modest (AUC 0.56 and 0.60). Cumulative mortality rates after 2 years were 15.9% vs. 5.6% in patients with a QRS &gt; 120 ms compared to a QRS duration &lt;= 120 ms (p &lt; 0.001), and 11.4% vs. 4.3% in patients with a QTc &gt; 440 ms compared to a QRS duration &lt;= 440 ms (p &lt; 0.001). After adjustment for age and important ECG and clinical parameters, the QTc interval but not QRS duration remained an independent predictor of mortality. Conclusions: Prolongation of QRS duration &gt; 120 ms and QTc interval &gt; 440 ms predict mortality in patients with suspected AMI, but do not add diagnostic value.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiology Journal

ISSN

1897-5593

e-ISSN

—

Volume of the periodical

25

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

601-610

UT code for WoS article

000449351400009

EID of the result in the Scopus database

2-s2.0-85056255777