Incomprehensible treatment of retinoblastoma with high doses of vitamin C

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069088" target="_blank" >RIV/65269705:_____/18:00069088 - isvavai.cz</a>
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=5826&session_id=rvkks1dln3ck5q10eevf6a7qa2" target="_blank" >http://www.elis.sk/download_file.php?product_id=5826&session_id=rvkks1dln3ck5q10eevf6a7qa2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2018_094" target="_blank" >10.4149/BLL_2018_094</a>

Result language
angličtina
Original language name
Incomprehensible treatment of retinoblastoma with high doses of vitamin C
Original language description
PURPOSES: To inform about a case of neglected retinoblastoma that was left untreated for more than 3 years by parents. During this time period the local finding worsened from endophytic retinoblastoma group B according IIRC (ABC classification) to extraorbital propagation. BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood, that occurs approximately in 1 : 15-20 000 births worldwide. In European region cases of extraocular propagation are very infrequent. Extraorbital propagation is extremely rare in middle and high income countries. METHODS: We report the preoperative ophthalmological findings, MRI imaging, treatment methods and postoperative results of this case. RESULTS: After initial dose of six courses of chemotherapy patient underwent surgery (orbital exenteration). In postoperative period patient received two more courses of chemotherapy. In spite of progressed stage of the disease, we obtained good results with our therapy. CONCLUSIONS: We suppose that good treatment results, in spite of extraordinary long lag interval and hopeless pretreatment condition, caused by alternative therapy with high doses vitamin C and no protein intake, were caused by therapeutic naive retinoblastoma with an absence of RB1 gene mutation (Fig. 6, Ref. 7).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30218 - General and internal medicine

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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