The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069110" target="_blank" >RIV/65269705:_____/18:00069110 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104136

Result on the web

<a href="http://dx.doi.org/10.1093/labmed/lmx076" target="_blank" >http://dx.doi.org/10.1093/labmed/lmx076</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/labmed/lmx076" target="_blank" >10.1093/labmed/lmx076</a>

Result language

angličtina

Original language name

The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

Original language description

Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P &lt;.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P &lt;.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P &lt;.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P &lt;.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Laboratory medicine

ISSN

0007-5027

e-ISSN

—

Volume of the periodical

49

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

112-117

UT code for WoS article

000435092600006

EID of the result in the Scopus database

2-s2.0-85044665182