Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069436" target="_blank" >RIV/65269705:_____/18:00069436 - isvavai.cz</a>
Result on the web
<a href="https://insight.jci.org/articles/view/97021" target="_blank" >https://insight.jci.org/articles/view/97021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1172/jci.insight.97021" target="_blank" >10.1172/jci.insight.97021</a>
Alternative languages
Result language
angličtina
Original language name
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Original language description
In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed for identification of noninvasive biomarkers with potential in monitoring metastatic disease, After determining the circulating neuroblastoma miRNome, 743 miRNAs were screened in 2 independent cohorts of 131 and 54 patients. Evaluation of serum miRNA variance in a model testing for tumor stage, MYCN status, age at diagnosis, and overall survival revealed tumor stage as the most significant factor impacting miRNA abundance in neuroblastoma serum. Differential abundance analysis between patients with metastatic and localized disease revealed 9 miRNAs strongly associated with metastatic stage 4 disease in both patient cohorts. Increasing levels of these miRNAs were also observed in serum from xenografted mice bearing human neuroblastoma tumors. Moreover, murine serum miRNA levels were strongly associated with tumor volume. These findings were validated in longitudinal serum samples from metastatic neuroblastoma patients, where the 9 miRNAs were associated with disease burden and treatment response.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JCI Insight
ISSN
2379-3708
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
"e97021"
UT code for WoS article
000452436000020
EID of the result in the Scopus database
2-s2.0-85063246149