Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069920" target="_blank" >RIV/65269705:_____/18:00069920 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104056

Result on the web

<a href="https://www.hindawi.com/journals/dm/2018/7628957/abs/" target="_blank" >https://www.hindawi.com/journals/dm/2018/7628957/abs/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2018/7628957" target="_blank" >10.1155/2018/7628957</a>

Result language

angličtina

Original language name

Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

Original language description

Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal peripheral blood and umbilical cord blood. Our study shows a possible association between cord blood irisin concentration and PTB occurrence.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30109 - Pathology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Disease Markers

ISSN

0278-0240

e-ISSN

—

Volume of the periodical

2018

Issue of the periodical within the volume

2018

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

7628957

UT code for WoS article

000434816400001

EID of the result in the Scopus database

2-s2.0-85055209726