Inflammatory bowel disease and Clostridium difficile infection: contrasting views of international clinical professionals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00070443" target="_blank" >RIV/65269705:_____/18:00070443 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00103950

Result on the web

<a href="http://dx.doi.org/10.1055/s-0044-100045" target="_blank" >http://dx.doi.org/10.1055/s-0044-100045</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0044-100045" target="_blank" >10.1055/s-0044-100045</a>

Result language

angličtina

Original language name

Inflammatory bowel disease and Clostridium difficile infection: contrasting views of international clinical professionals

Original language description

Introduction In patients with inflammatory bowel disease (IBD), Clostridium difficile infection (CDI) is a risk factor for both morbidity and mortality. Currently, appropriate management is unclear. Guidance on best practice in the diagnosis and treatment of CDI in IBD patients is therefore needed. Methods A multidisciplinary group of clinicians involved in the treatment of patients with IBD and CDI developed 27 consensus statements. Respondents were asked to rate their agreement with each statement using a 4-point Likert scale. Amodified Delphi methodology was used to review responses of 442 physicians from different specialties (including infectious disease specialists [n = 104], microbiologists [n = 95], and gastroenterologists [n = 73]). A threshold of 75 % agreement was predefined as consensus. Results Consensus was achieved for 17 of the 27 statements. Unprompted recognition of risk factors for CDI was low. Intensification of immunosuppressive therapy in the absence of clinical improvement was controversial. Clear definitions of treatment failure of antibiotic therapy in CDI and recurrence of CDI in IBD are needed. Respondents require further clarity regarding the place of fecal microbiota transplantation in CDI patients with IBD. Differences were observed between the perceptions of microbiologists and gastroenterologists, as well as between countries. Conclusions Different perceptions both between specialties and geographical locations complicate the development of an internationally accepted algorithm for the diagnosis and treatment of CDI in patients with IBD. This study highlights the need for future studies in this area.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Zeitschrift für Gastroenterologie

ISSN

0044-2771

e-ISSN

—

Volume of the periodical

56

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

731-737

UT code for WoS article

000437861800016

EID of the result in the Scopus database

2-s2.0-85042185611