The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070515" target="_blank" >RIV/65269705:_____/19:00070515 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00108963

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs00384-018-3122-7" target="_blank" >https://link.springer.com/article/10.1007%2Fs00384-018-3122-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00384-018-3122-7" target="_blank" >10.1007/s00384-018-3122-7</a>

Result language

angličtina

Original language name

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease

Original language description

PurposeCrohn&apos;s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery).MethodsThe patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects.ResultsIn total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum.ConclusionThe group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Colorectal Disease

ISSN

0179-1958

e-ISSN

—

Volume of the periodical

34

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

347-351

UT code for WoS article

000455824400018

EID of the result in the Scopus database

2-s2.0-85051211787