Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070542" target="_blank" >RIV/65269705:_____/19:00070542 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00109543

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2352906719300132" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352906719300132</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcha.2019.02.011" target="_blank" >10.1016/j.ijcha.2019.02.011</a>

Result language

angličtina

Original language name

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Original language description

Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the presence of AHF at admission or its occurrence during hospitalization. Methods and results: The study population consisted of 927 prospectively enrolled patients with ACS. Blood samples for the measurement of plasma bio-adrenomedullin (bio-ADM) were collected at admission. Patients with alveolar pulmonary edema and interstitial pulmonary edema on chest radiography at admission had step-wise higher plasma concentrations of bio-ADM compared to patients with no or mild pulmonary congestion: 54.3 +/- 10.6 vs. 27.6 +/- 2.1 vs. 22.5 +/- 0.7 ng/L, overall P &lt; 0.001. Patients with ACS complicated by AHF during the index hospitalization displayed higher plasma bio-ADM concentrations at admission compared to patients without AHF (33.8 +/- 2.7 vs. 21.8 +/- 0.7, P &lt; 0.001): the higher the severity of AHF, the higher plasma bio-ADM concentrations at admission. Patients with cardiogenic shock displayed the highest values. Accordingly, bio-ADM concentrations at admission were associated with a higher risk of occurrence of AHF during index hospitalization (odds ratio 1.018, 95% confidence interval 1.011-1.026, P &lt; 0.001). Conclusions: Plasma adrenomedullin is a marker associated with AHF severity in patients with ACS.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

IJC Heart &amp; Vasculature

ISSN

2352-9067

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

MAR 2019

Country of publishing house

IE - IRELAND

Number of pages

3

Pages from-to

174-176

UT code for WoS article

000462184100037

EID of the result in the Scopus database

2-s2.0-85062494828