Patterns in anticoagulant utilization in the Czech Republic during 2007-2017
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070859" target="_blank" >RIV/65269705:_____/19:00070859 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00113752 RIV/00216208:11160/19:10400825
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11239-019-01806-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs11239-019-01806-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11239-019-01806-z" target="_blank" >10.1007/s11239-019-01806-z</a>
Alternative languages
Result language
angličtina
Original language name
Patterns in anticoagulant utilization in the Czech Republic during 2007-2017
Original language description
Direct oral anticoagulants (DOACs) have gradually entered the Czech market as alternatives to vitamin K antagonists and parenteral anticoagulants since 2008. Considering the eventual changes, the aim was to evaluate drug use and expenditure patterns on anticoagulants in the Czech Republic. A retrospective utilization study was conducted retrieving data from the State Institute for Drug Control database, including reports on drug supplies from distributors with anatomical therapeutic chemical classification (ATC) codes B01AA, B01AB, B01AE, B01AF, and B01AX. The utilization on national level was expressed as the ratio of the number of defined daily doses per 1000 inhabitants per day (DDD/TID). Expenditures on all anticoagulants were also assessed. Data was analyzed using PASW (version 18.0). Between January 2007 and December 2017, the national anticoagulant utilization rate increased continuously from 14.15 to 27.67 DDD/TID. The use of DOACs was 0.002 DDD/TID in 2008, increased to 6.04 DDD/TID in 2017. Warfarin utilization, after a small decrease in 2008, has shown nearly stable levels in the recent years (70.9% of all anticoagulants; mean 11.55 DDD/TID over the last 5years), while its increase was halted by the spread of DOACs utilization (p<0.05). In 2017, over half of the expenditures (51.1%) were due to oral anticoagulants, whereof 47.6% was related to DOACs. The results reflected a growing utilization and increasing costs of all anticoagulants, especially in DOACs at the expense of warfarin. Still, additional information regarding patient persistence and prescribing patterns is needed for a better understanding of oral anticoagulant utilization.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Thrombosis and Thrombolysis
ISSN
0929-5305
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
305-311
UT code for WoS article
000459806100019
EID of the result in the Scopus database
2-s2.0-85060235120