Human Wharton’s jelly Mesenchymal stem cells: Properties, isolation and clinical applications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070867" target="_blank" >RIV/65269705:_____/19:00070867 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00113003
Result on the web
<a href="https://www.biolifesas.org/biolife/2019/02/19/human-whartons-jelly-mesenchymal-stem-cells-properties-isolation-and-clinical-applications/" target="_blank" >https://www.biolifesas.org/biolife/2019/02/19/human-whartons-jelly-mesenchymal-stem-cells-properties-isolation-and-clinical-applications/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Human Wharton’s jelly Mesenchymal stem cells: Properties, isolation and clinical applications
Original language description
Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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