Different time-dependent changes of risk for evolution in chronic lymphocytic leukemia with mutated or unmutated antigen B cell receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070996" target="_blank" >RIV/65269705:_____/19:00070996 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00109738
Result on the web
<a href="https://www.nature.com/articles/s41375-018-0322-7" target="_blank" >https://www.nature.com/articles/s41375-018-0322-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-018-0322-7" target="_blank" >10.1038/s41375-018-0322-7</a>
Alternative languages
Result language
angličtina
Original language name
Different time-dependent changes of risk for evolution in chronic lymphocytic leukemia with mutated or unmutated antigen B cell receptors
Original language description
Chronic lymphocytic leukemia (CLL) displays remarkable clinical heterogeneity, likely attributed to the underlying biological diversity [1]. This claim is supported by the fact that certain immunogenetic and/or genomic features identify subgroups of CLL patients with distinct prognosis and outcome [2,3,4]. Indeed, determination of the somatic hypermutation (SHM) status of the immunoglobulin heavy variable (IGHV) genes expressed by the clonotypic B cell receptor (BcR) and screening for aberrations οf the TP53 gene are nowadays considered essential for clinical decision making [5]. A cautionary note appears warranted when utilizing biomarkers, where the prognosis is usually assessed assuming stable predictability over the disease course; this hypothesis, however, is often unrealistic as it concerns genomic aberrations [6, 7]. Therefore, arguably, the prognostic power of a given biomarker may, instead, heavily depend on the time distance from diagnosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
—
Volume of the periodical
33
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
1801-1805
UT code for WoS article
000473724900022
EID of the result in the Scopus database
2-s2.0-85060671726