Analysis of microRNA levels in cerebrospinal fluid of patients with primary brain tumors and metastases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00071459" target="_blank" >RIV/65269705:_____/19:00071459 - isvavai.cz</a>
Result on the web
<a href="https://wfns2019.medmeeting.org/Home/AbstractSearchEn/8292" target="_blank" >https://wfns2019.medmeeting.org/Home/AbstractSearchEn/8292</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Analysis of microRNA levels in cerebrospinal fluid of patients with primary brain tumors and metastases
Original language description
Primary brain tumors and brain metastases counts yearly around 40 patients per 100 000 persons in the world and their incidence rate is still growing. Prognosis and therapy differ between brain tumor types and, therefore, accurate and early diagnosis might improve survival and life quality of patients. Cerebrospinal fluid (CSF) has many important functions and baths extracellular environment of the central nervous system, and thus is supposed to reflect all pathological conditions. From this perspective, CSF looks as ideal source of diagnostic biomarkers. MikroRNAs (miRNAs), short non-coding RNAs involved in the pathogenesis of many cancers including brain tumors, might represent group of new biomarkers. In addition, dysregulated levels of brain tumor specific miRNAs have been already observed also in CSF. Following these facts, analysis of CSF miRNAs in brain tumor patients might help to develop new diagnostic platform enabling more precise diagnosis. We have observed that CSFs from patients with various primary brain tumors and metastases are characterized by specific miRNA signatures.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NV18-03-00398" target="_blank" >NV18-03-00398: Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů