Tuberculosis in elderly in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00072352" target="_blank" >RIV/65269705:_____/19:00072352 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112821

Result on the web

<a href="https://www.prolekare.cz/casopisy/epidemiologie/2019-4-15/tuberkuloza-u-senioru-v-ceske-republice-119840" target="_blank" >https://www.prolekare.cz/casopisy/epidemiologie/2019-4-15/tuberkuloza-u-senioru-v-ceske-republice-119840</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Tuberculosis in elderly in the Czech Republic

Original language description

Introduction: The incidence of tuberculosis (TB) in the Czech Republic (CR) is decreasing since 1960s. (1965: 76.9; 1975: 60.4; 1985: 45.2; 1995: 17.7; 2005: 9.9; 2015: 4.9 per 100, 000 population). In 2017 men accounted for over than 70% of cases. People aged over 75 years are most frequently affected. Elderly patients tend to develop more of extrapulmonary and atypical manifestation of the disease, the diagnosis of TB can be difficult and consequently overlooked. Multimorbid seniors are suffering from chronic illnesses,malignancies and autoimmune diseases, which translate into higher degree of immunosuppression and add to the generally described process of immunosenescence. Furthermore, therapy of TB in the elderly is challenging because of the increased drug resistance and higher incidence of adverse drug reactions. This article reviews the epidemiology of TB in the CR, immunological aspects, clinical characteristics, diagnosis, management,prevention of TB infection and presents two clinical cases in hospitalized aging adults in the CR. Case presentation: We present a case of a 79 year old female suffering from chronic obstructive pulmonary disease (COPD),who was repeatedly hospitalized for acute exacerbations of COPD and was consequently diagnosed with TB. Patient developed manifestation of treatment toxicity and drug interactions due to comorbidities and other medications. Secondly, we present a case of a 70 year old male, a lifelong smoker, who was initially admitted for collapsing. TB developed via the endogenic route from a Ghon&apos;s complex in association with a slowly progressing bronchogenic carcinoma. Conclusion: Diagnosis and management of TB in the elderly person can be challenging. Age-related factors increase the risk of TB reactivation as well as enhance susceptibility to TB infection.In elderly population we find accumulation of risk factors for developing TB (malnutrition, low socio economic status, smokingand alcoholism). The people most at risk among elderly include fragile institutionalized seniors whose incidence of TB is 2-3 times higher than those living at home. Because the number of seniors is growing and the incidence of TB in this subpopulation is increasing, detailed knowledge of the epidemiological features of TB in this group is needed to optimize healthcare services.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epidemiologie, mikrobiologie, imunologie

ISSN

1210-7913

e-ISSN

—

Volume of the periodical

68

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

184-190

UT code for WoS article

000510477900004

EID of the result in the Scopus database

2-s2.0-85077696051