Ovarian follicular cells - Living in the shadow of stemness cellular competence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00072388" target="_blank" >RIV/65269705:_____/19:00072388 - isvavai.cz</a>
Result on the web
<a href="https://content.sciendo.com/view/journals/acb/7/3/article-p134.xml" target="_blank" >https://content.sciendo.com/view/journals/acb/7/3/article-p134.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/acb-2019-0018" target="_blank" >10.2478/acb-2019-0018</a>
Alternative languages
Result language
angličtina
Original language name
Ovarian follicular cells - Living in the shadow of stemness cellular competence
Original language description
Granulosa cells (GCs) are a major component found in ovarian follicular fluid among oocytes, theca cells, and ovarian surface epithelial (OSE) cells. GCs are steroidogenic and have morphological functions that are important for the development of the follicular follicle. The follicle protects the developing female egg. GCs are also essential for the maturation of the female germ cell. Stem cell properties have been found in luteinised GCs and in vivo cultures have the potential to differentiate to become cells found outside of the ovary. Both three-dimensional (3D) culturing and mouse embryonic fibroblast (MEF) medium have been used to help improve the culturing lifespan of GCs so that their profound proliferation and differentiation capabilities can be studied. Small RNAs called MicroRNAs (miRNAs) are released from exosomes originating from GCs, and they are involved in transforming growth factor (TGF)-β signalling, follicle-stimulating hormone, hormone-related miRNAs, and apoptosis-related pathway. Finding the miRNAs involved in these pathways, and the mechanisms controlling GCs are important to treating conditions like polycystic ovary syndrome (PCOS), and creating new drug therapies. Besides GCs, ovarian stem cells (OSCs) were discovered in the OSE, and they are believed to be derived from very small embryonic stem cells (VSELs). Transplanting blood mononuclear cells, cell Hormone Therapy (cHT) with bone marrow stem cell supplement and increasing vitamin C levels are all therapies currently being researched into that involve GCs to combat the effects of aging and infertility.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medical Journal of Cell Biology
ISSN
2544-3577
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
3
Country of publishing house
PL - POLAND
Number of pages
7
Pages from-to
134-140
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85075124509